BDBM50031873 5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-quinazoline-2,4-diamine::5-chloro-6-((2,5-dimethoxyphenylamino)methyl)quinazoline-2,4-diamine::CHEMBL88430

SMILES COc1ccc(OC)c(NCc2ccc3nc(N)nc(N)c3c2Cl)c1

InChI Key InChIKey=KEPKKUKRTDFXHZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50031873   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 30nMAssay Description:Concentration inhibiting Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 51nMAssay Description:Concentration inhibiting Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 44nMAssay Description:Concentration inhibiting rat liver dihydrofolate reductase. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
Dartmouth College

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of Cryptosporidium hominis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 44nMAssay Description:Inhibition of Dihydrofolate reductase (DHFR) of in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 51nMAssay Description:Inhibition of Dihydrofolate reductase of Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031873(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Dihydrofolate reductase of Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed