BDBM50031793 (R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-hexanoic acid::CHEMBL85933

SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCC(O)=O)CC(=O)NO

InChI Key InChIKey=NBDGYUOAVSOSOD-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50031793   

TargetNeutrophil collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031793((R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-...)
Affinity DataKi:  270nMAssay Description:Inhibition of human neutrophil collagenase (HNC), MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031793((R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-...)
Affinity DataKi:  270nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031793((R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-...)
Affinity DataKi:  3.35E+3nMAssay Description:Inhibitory potency against human fibroblast collagenase, MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031793((R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-...)
Affinity DataKi:  3.35E+3nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031793((R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031793((R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 (potent inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article