BDBM50031790 (R)-N*4*-Hydroxy-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-2-(5-phenoxy-pentyl)-succinamide::(R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-2-(5-phenoxypentyl)succinamide::CHEMBL59023

SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCCOc1ccccc1)CC(=O)NO

InChI Key InChIKey=RRLGEVWMENCJGJ-UHFFFAOYSA-N

Data  11 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50031790   

TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant stromelysin (MMP-3, HFS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataIC50: 0.310nMAssay Description:Compound concentration for 50% inhibition of human recombinant gelatinase A (MMP-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataIC50: 26nMAssay Description:50% inhibition of human recombinant fibroblast collagenase (MMP-1, HFC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetNeutrophil collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi: <2nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetNeutrophil collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi: <2nMAssay Description:Inhibition of human Matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  14nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  14nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  14nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  14nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  26nMAssay Description:Inhibitory potency against human fibroblast collagenase, MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  26nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi:  26nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031790((R)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phe...)
Affinity DataKi: <100nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 (potent inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article