BDBM50031778 (R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide::(R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide::CHEMBL87229

SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCOCc1ccccc1)CC(=O)NO

InChI Key InChIKey=IYJLBIPCLHKYKU-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50031778   

TargetNeutrophil collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  2nMAssay Description:Inhibition of human neutrophil collagenase (HNC), MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi: <2nMAssay Description:Inhibition of human Matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  15nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  15nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 (potent inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  15nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  15nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi: <100nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 (potent inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  1.45E+3nMAssay Description:Inhibitory potency against human fibroblast collagenase, MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  1.45E+3nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50031778((R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article