BDBM50031704 (2S,4R)-2-Amino-4-methyl-pentanedioic acid::(2S,4R)-2-amino-4-methylpentanedioic acid::(2S,4R)-4-methylglutamic acid::2-Amino-4-methyl-pentanedioic acid::CHEMBL288166

SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O

InChI Key InChIKey=KRKRAOXTGDJWNI-UHFFFAOYSA-N

Data  7 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50031704   

TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataIC50: 7.00E+3nMAssay Description:Ability to inhibit [3H]CGS-19,755 binding to AMPA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataIC50: 1.00E+5nMAssay Description:Ability to inhibit [3H]AMPA binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  0.663nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  5.69nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  10nMAssay Description:Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to human EAAT2 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed