BDBM50031616 CHEMBL3359761

SMILES COC(C)(C)C#Cc1cnc2Oc3ccc(cc3[C@@]3(COC(N)=N3)c2c1)-c1cccnc1F

InChI Key InChIKey=NSZIOJJFVANMBW-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50031616   

TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBeta-secretase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed