BDBM50031481 (2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol::2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine::2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine::CHEMBL312653

SMILES C([C@@H]1[C@H]([C@@H]([C@H](N1)CO)O)O)O

InChI Key InChIKey=PFYHYHZGDNWFIF-UHFFFAOYSA-N

Data  18 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50031481   

TargetLactase/phlorizin hydrolase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Wistar rat intestinal lactaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 1.71E+5nMAssay Description:Inhibition of human lysosomal acid beta-glucosidase incubated for 30 mins by fluorescence based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of rat isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen debranching enzyme(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of rat sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 2.90E+5nMAssay Description:Inhibition of rat intestinal maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAlpha-glucosidase MAL62(Baker's yeast)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometricallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-mannosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of lysosomal Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of Wistar rat liver lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of Wistar rat intestinal isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 2.90E+5nMAssay Description:Inhibition of Wistar rat intestinal maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrehalase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 3.60E+5nMAssay Description:Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactase/phlorizin hydrolase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed