BDBM50031297 7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 2HCl::CHEMBL553331

SMILES Cn1c2ncn(CCCN3CCN(CC3)C(c3ccc(F)cc3)c3ccc(F)cc3)c2c(=O)n(C)c1=O

InChI Key InChIKey=VOEUXHROHLFPEE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50031297   

TargetHistamine H1 receptor(Guinea pig)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50031297(7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1...)
Affinity DataIC50: 220nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50031297(7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1...)
Affinity DataIC50: 38nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50031297(7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1...)
Affinity DataIC50: 670nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50031297(7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50031297(7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1...)
Affinity DataIC50: 43nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed