BDBM50029944 5,6-Dimethoxy-2-[1-(3-methyl-benzyl)-piperidin-4-ylmethyl]-indan-1-one; hydrochloride::CHEMBL170946::CHEMBL544860

SMILES COc1cc2CC(CC3CCN(Cc4cccc(C)c4)CC3)C(=O)c2cc1OC

InChI Key InChIKey=QBOHSSFTEGRUFM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50029944   

TargetAcetylcholinesterase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50029944(CHEMBL544860 | CHEMBL170946 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Acetylcholinesterase activity in mouse brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetAcetylcholinesterase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50029944(CHEMBL544860 | CHEMBL170946 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029944(CHEMBL544860 | CHEMBL170946 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 108nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029944(CHEMBL544860 | CHEMBL170946 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of equine serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029944(CHEMBL544860 | CHEMBL170946 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029944(CHEMBL544860 | CHEMBL170946 | 5,6-Dimethoxy-2-[1-(...)
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of human serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed