BDBM50029426 CHEMBL24675::[2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-(4-methoxy-phenyl)-4H-benzo[b]pyrrolo[1,2-d][1,4]thiazin-1-ylmethyl]-methyl-amine

SMILES COc1ccc(cc1)C1Sc2ccccc2-n2c(CN(C)CCc3ccc(OC)c(OC)c3)ccc12

InChI Key InChIKey=KIYASJXFIUZQLU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50029426   

LigandPNGBDBM50029426([2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-(4-methoxy-phe...)
Affinity DataIC50: 53nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rat)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50029426([2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-(4-methoxy-phe...)
Affinity DataIC50: 52nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50029426([2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-(4-methoxy-phe...)
Affinity DataKi:  8.30nMAssay Description:Calcium antagonistic activity by measuring [3H]nitrendipine displacement from rat heart L-type [Ca2+] channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50029426([2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-(4-methoxy-phe...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details