BDBM500289 US11021475, Example 61::US11021475, Example 76

SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC

InChI Key InChIKey=NHLVZGANYDEFNZ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 500289   

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM500289(US11021475, Example 76 | US11021475, Example 61)
Affinity DataEC50:  1.66nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM500289(US11021475, Example 76 | US11021475, Example 61)
Affinity DataEC50:  6.17nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent