BDBM50028366 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethylsulfanyl]-benzoylamino}-pentanedioic acid::2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethylsulfanyl]-benzoylamino}-pentanedioic acid (11-Thiohomoaminopterin)::CHEMBL10592

SMILES Nc1nc(N)c2nc(CCSc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1

InChI Key InChIKey=FXGBKUVTNNFJHR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50028366   

TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50028366(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethylsulfanyl]...)
Affinity DataIC50: 400nMAssay Description:Ability to inhibit Lactobacillus casei dihydrofolate reductase in vitro was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50028366(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethylsulfanyl]...)
Affinity DataIC50: 6.00E+4nMAssay Description:Ability to inhibit Lactobacillus casei thymidylate synthase in vitro was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50028366(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethylsulfanyl]...)
Affinity DataIC50: 400nMAssay Description:Concentration required to inhibit Lactobacillus casei derived Dihydrofolate reductase activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50028366(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethylsulfanyl]...)
Affinity DataIC50: 400nMAssay Description:Ability to inhibit Lactobacillus casei dihydrofolate reductase in vitro was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed