BDBM50028147 2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol::2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(15S)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol(Buprenorphine)::BUPRENORPHINE::Buprenorphine(+)::Buprenorphine(-)::Buprenorphine2-(3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl)-3,3-dimethyl-2-butanol(::CHEMBL560511

SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45

InChI Key

Data  17 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50028147   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  0.420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  0.510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Guinea pig)
Loughborough University

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  0.570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Pig)
Loughborough University

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Guinea pig)
Loughborough University

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Pig)
Loughborough University

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  4.18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  12.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetDelta-type opioid receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  25.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50028147(BUPRENORPHINE | Buprenorphine2-(3-cyclopropylmethy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed