BDBM50028035 CHEMBL3338839

SMILES C1CN(CCN1)c1nc(nc2cnccc12)-c1ccc2[nH]ncc2c1

InChI Key InChIKey=GMLKJSOWCKBKLX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50028035   

TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 36nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 974nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 507nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 785nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed