BDBM50028033 CHEMBL3338837::US11458138, Example 312

SMILES CC(C)(N)CNc1nc(nc2cnccc12)-c1ccncc1

InChI Key InChIKey=KSKYRXFKNPXFGI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50028033   

TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 99nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase LATS1(Human)
Novartis

US Patent
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 2.40nMAssay Description:The LATS1 biochemical Caliper assay was performed as following.Human LATS1 kinase domain protein was purchased from Carnabio (catalogue number 01-123...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent