BDBM50027828 (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid::3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-6-ium-7-carboxylate(7-HPCA)::CHEMBL154535

SMILES [O-]C(=O)C1[NH2+]CCc2c1o[nH]c2=O

InChI Key InChIKey=YRSIGIYXZNQZCI-UHFFFAOYSA-N

Data  8 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50027828   

TargetGlutamate receptor 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataEC50:  8.28E+4nMAssay Description:Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataEC50:  3.46E+4nMAssay Description:Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataEC50:  6.37E+5nMAssay Description:Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]AMPA from GluA2-S1S2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  348nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA2(R)o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  4.48E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK1(Q)1b expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  4.52E+3nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  1.35E+4nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA4o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  2.98E+4nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK3a expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK2(VCR)a expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed