BDBM50025573 1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione::CHEMBL24774

SMILES O=c1n(Cc2ccccc2)c2nc[nH]c2c(=O)n1Cc1ccccc1

InChI Key InChIKey=NHCLZKKZQJJXER-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50025573   

TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025573(1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione | CHEMBL...)
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonism of adenosine A1 receptor assessed from the ability to inhibit binding of [3H]cyclohexyladenosine to rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025573(1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione | CHEMBL...)
Affinity DataKi:  2.00E+3nMAssay Description:Ability to inhibit binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025573(1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione | CHEMBL...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]PIA from adenosine A1 receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50025573(1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione | CHEMBL...)
Affinity DataKi:  1.40E+4nMAssay Description:Compound was evaluated for its ability to antagonise cyclic [3H]AMP accumulation in [3H]adenine-labeled guinea pig cerebral cortical slices.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed