BDBM50025020 CHEMBL3337854

SMILES c1ccc(c(c1)C(=O)Nc2nc(cs2)C(=O)Nc3[nH]c4cc(ccc4n3)C(F)(F)F)OC(F)(F)F

InChI Key InChIKey=GUWQZSKMUJFZMM-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50025020   

TargetCasein kinase I isoform epsilon(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 199nMAssay Description:Inhibition of human recombinant CK1epsilon expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 40nMAssay Description:Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 29nMAssay Description:Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant rat GST-tagged CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) as substrate by SDS-PAGE based autor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform epsilon(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 199nMAssay Description:Inhibition of recombinant human CK1epsilon using GST-p53 (1 to 64 residues) as substrate by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 22nMAssay Description:Inhibition of human CK1delta transcription variant 1 using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat recombinant GST-tagged CK1delta using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by Cher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025020(CHEMBL3337854)
Affinity DataIC50: 42nMAssay Description:Inhibition of human CK1delta transcription variant 2 using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)