BDBM50025019 CHEMBL3337845

SMILES c1ccc(c(c1)C(=O)Nc2nc(cs2)C(=O)Nc3[nH]c4cc5c(cc4n3)OC(O5)(F)F)OC(F)(F)F

InChI Key InChIKey=DVVVOLSRHWJCHV-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50025019   

TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 5.59E+4nMAssay Description:Inhibition of GST-tagged mouse CK1delta transcription variant 2 mutant expressed in Escherichia coli at 37 degC for 2 hrs using GST-p53 (1 to 64 resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of GST-tagged mouse CK1delta transcription variant 2 mutant expressed in Escherichia coli at 15 degC for 14 hrs using GST-p53 (1 to 64 res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 8.01E+4nMAssay Description:Inhibition of GST-tagged mouse CK1delta transcription variant 1 mutant expressed in Escherichia coli at 37 degC for 2 hrs using GST-p53 (1 to 64 resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of GST-tagged mouse CK1delta transcription variant 1 mutant expressed in Escherichia coli at 15 degC for 14 hrs using GST-p53 (1 to 64 res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform epsilon(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant CK1epsilon expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 70nMAssay Description:Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 20nMAssay Description:Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform gamma-3(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 810nMAssay Description:Inhibition of GST-tagged human CK1gamma3 expressed in Escherichia coli using using alpha casein substrate by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Bovine)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged bovine CK1alpha expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform epsilon(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant CK1epsilon expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50025019(CHEMBL3337845)
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)