BDBM50023040 CHEMBL2272783

SMILES CC1=C(C)C(C)(C)C(=C)C1=O

InChI Key InChIKey=HPRXOWFUCCMLJF-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50023040   

TargetBeta-secretase 1(Chinese hamster)
University of Coimbra

Curated by ChEMBL
LigandPNGBDBM50023040(CHEMBL2272783)
Affinity DataEC50:  7.30E+4nMAssay Description:Inhibition of BACE-1 in CHO cells expressing wild-type APP assessed as reduction in amyloid beta-40 production after 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Coimbra

Curated by ChEMBL
LigandPNGBDBM50023040(CHEMBL2272783)
Affinity DataEC50:  2.17E+5nMAssay Description:Inhibition of BACE-1 in human SH-SY5Y cells expressing wild-type APP assessed as reduction in amyloid beta-40 production after 16 hrs by sandwich ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Coimbra

Curated by ChEMBL
LigandPNGBDBM50023040(CHEMBL2272783)
Affinity DataKi:  3.08E+4nMAssay Description:Inhibition of cathepsin D in human liver using Lys-Lys-Pro-Ala-Glu-Phe-Phe-Ala-Leu-Lys as substrate by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Coimbra

Curated by ChEMBL
LigandPNGBDBM50023040(CHEMBL2272783)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of cathepsin D in human liver using Lys-Lys-Pro-Ala-Glu-Phe-Phe-Ala-Leu-Lys as substrate by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Coimbra

Curated by ChEMBL
LigandPNGBDBM50023040(CHEMBL2272783)
Affinity DataKi:  4.16E+5nMAssay Description:Inhibition of recombinant BACE-1 (unknown origin) expressed in Escherichia coli measured for 5 to 30 mins by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Coimbra

Curated by ChEMBL
LigandPNGBDBM50023040(CHEMBL2272783)
Affinity DataKi:  4.16E+5nMAssay Description:Inhibition of recombinant BACE-1 (unknown origin) expressed in Escherichia coli measured for 5 to 30 mins by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed