BDBM50022725 1,3-Diallyl-3,7-dihydro-purine-2,6-dione::CHEMBL286785

SMILES C=CCn1c2nc[nH]c2c(=O)n(CC=C)c1=O

InChI Key InChIKey=NUZFZZOVBJUJQN-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50022725   

TargetAdenosine receptor A2a/A2b(Rat)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  820nMAssay Description:Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  1.33E+3nMAssay Description:Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  5.00E+3nMAssay Description:Compound was evaluated for its ability to antagonise cyclic [3H]AMP accumulation in [3H]adenine-labeled guinea pig cerebral cortical slices.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of 2-CADO-stimulated adenylate cyclase at Adenosine A2 receptor in guinea pig cerebral cortical slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  1.00E+4nMAssay Description:Binding of 1 nM [3H]CHA to Adenosine A1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  1.00E+4nMAssay Description:Ability to inhibit binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity at A1 adenosine receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50022725(1,3-Diallyl-3,7-dihydro-purine-2,6-dione | CHEMBL2...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed