BDBM50022542 CHEMBL3297898::US10189853, Compound 1

SMILES COc1ccc(cc1)N(C)c1nc(C)nc2oc(C)cc12

InChI Key InChIKey=KVMLMFRXRZLEGU-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50022542   

TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 22nMAssay Description:Inhibition of PDGFRbeta in human SH-SY5Y cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 20nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 23nMAssay Description:Inhibition of PDGFRbeta in human SH-SY5Y cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 68nMAssay Description:Inhibition of EGFR in human A431 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 82nMAssay Description:Inhibition of EGFR in human A431 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 23nMAssay Description:Inhibition of PDGFR-beta in human U251 cells compound pretreated for 60 min before PDGF-BB stimulation for 10 mins by phosphotyrosine ELISA cytoblot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 68nMAssay Description:Inhibition of EGFR in human A431 cells compound pretreated for 60 min before EGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of bovine brain tubulin assemblyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 68.2nMAssay Description:RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 19.1nMAssay Description:RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM50022542(CHEMBL3297898 | US10189853, Compound 1)
Affinity DataIC50: 22.8nMAssay Description:RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent