BDBM50022495 6,7,8,9-tetrahydro-2'H,5'H-spiro[benzo[7]annulene-5,4'-imidazolidine]-2',5'-dione::6,7,8,9-tetrahydrospiro[benzo[7]annulene-5,4'-imidazolidine]-2',5'-dione::CHEMBL39377::spiro[6,7,8,9-tetrahydro-5H-benzo[a]cycloheptene-5,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione

SMILES O=C1NC(=O)C2(CCCCc3ccccc23)N1

InChI Key InChIKey=BCSYSQVTCKMBMK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50022495   

LigandPNGBDBM50022495(spiro[6,7,8,9-tetrahydro-5H-benzo[a]cycloheptene-5...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50022495(spiro[6,7,8,9-tetrahydro-5H-benzo[a]cycloheptene-5...)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50022495(spiro[6,7,8,9-tetrahydro-5H-benzo[a]cycloheptene-5...)
Affinity DataIC50: 2.51E+5nMAssay Description:In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synapto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed