BDBM50021895 4-(3,4-Dichloro-phenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline::4-(3,4-Dichloro-phenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline(Diclofensive)::CHEMBL287257::DICLOFENSINE,(+)::DICLOFENSINE,(-)::Diclofensine

SMILES COc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=ZJDCGVDEEHWEIG-UHFFFAOYSA-N

Data  22 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50021895   

LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  3.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  4.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
In Depth
Date in BDB:
2/3/2012
Entry Details
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  8.80nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  10nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  11nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  15nMAssay Description:Inhibition of dopamine (DA) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  15.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  16.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  18nMAssay Description:Inhibition of serotonin (5-HT) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  37nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  51nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  606nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details
PubMed
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi:  3.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50021895(CHEMBL287257 | DICLOFENSINE,(-) | 4-(3,4-Dichloro-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed