BDBM50020888 (S)-Piperidine-3-carboxylic acid::(S)-nipecotic acid::CHEMBL77484

SMILES C1C[C@@H](CNC1)C(=O)O

InChI Key InChIKey=XJLSEXAGTJCILF-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50020888   

TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 4.96E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.73E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.66E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.78E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.83E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.10E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.66E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.78E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.32E+6nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.83E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.83E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.97E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.97E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 7.63E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 6.41E+6nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 2.32E+6nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed