BDBM50020483 CHEMBL3290141

SMILES Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1C(=O)Nc1cnc(Nc2cccc(N)c2)nc1

InChI Key InChIKey=PPGPPDAKFCUXOF-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50020483   

TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataIC50: 39nMAssay Description:Inhibition of Btk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type N-terminal GST tagged BLK (unknown origin) (1 to 505 residues) expressed in sf21 insect cell using TK as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataIC50: 79nMAssay Description:Inhibition of wild type N-terminal GST tagged BTK (unknown origin) (2 to 659 residues) expressed in sf21 insect cell using TK as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataEC50:  12nMAssay Description:Induction of ubiquitin proteasomal system dependent BLK degradation in human Ramos cells measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal GST tagged BLK (1 to 505 end residues) (unknown origin) expressed in Sf21insect cells by time resolved fluorescence based as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataIC50: 79nMAssay Description:Inhibition of full length N-terminal GST tagged BTK (2 to 659 end residues) (unknown origin) expressed in Sf21insect cells by time resolved fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50020483(CHEMBL3290141)
Affinity DataIC50: 100nMAssay Description:Inhibition of SYK phosphorylation in human Ramos cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed