BDBM50019393 4-(2-Dipropylamino-ethyl)-7-hydroxy-1,3-dihydro-indol-2-one::7-Hydroxy Ropinirole::CHEMBL587

SMILES CCCN(CCC)CCc1ccc(O)c2NC(=O)Cc12

InChI Key InChIKey=PVIICBUWKXYFAA-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50019393   

TargetD(2) dopamine receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50019393(CHEMBL587 | 7-Hydroxy Ropinirole | 4-(2-Dipropylam...)
Affinity DataIC50: 530nMAssay Description:Displacement of [3H]spiroperidol from homogenized bovine pituitary Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019393(CHEMBL587 | 7-Hydroxy Ropinirole | 4-(2-Dipropylam...)
Affinity DataEC50:  2.00E+4nMAssay Description:Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50019393(CHEMBL587 | 7-Hydroxy Ropinirole | 4-(2-Dipropylam...)
Affinity DataEC50:  1.80nMAssay Description:Tested in vitro for dopamine agonist activity in rabbit ear artery after at a dose of 0.3 mg/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50019393(CHEMBL587 | 7-Hydroxy Ropinirole | 4-(2-Dipropylam...)
Affinity DataEC50:  1.80nMAssay Description:Inhibitory activity against constrictor response to electrical stimulation in the isolated perfused rabbit ear artery(REA) expressing dopamine recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2018
Entry Details Article
PubMed