BDBM50019252 1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide::1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide: 0.2C4H10O::CCK antagonist synthetic 14::CHEMBL306760

SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1

InChI Key InChIKey=PQCDUNADCLPZMS-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50019252   

TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataIC50: 4.70nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataIC50: 4.00E+3nMAssay Description:Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataIC50: 4.57nMAssay Description:Binding affinity against cholecystokinin type A receptor of rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataIC50: 8.00E+3nMAssay Description:Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Phosphodiesterase 3 extracted from dog aorta smooth muscle cells by using radioligands [3H]cAMP or [3H]-cGMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetCholecystokinin(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019252(CHEMBL306760 | CCK antagonist synthetic 14 | 1H-In...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2011
Entry Details Article
PubMed