BDBM50019242 2-(3',4'-Dihydroxyphenyl)quinazolin-4(3H)-one (5)::CHEMBL3289117

SMILES Oc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1

InChI Key InChIKey=VQZGOTKVGJAWAS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50019242   

TargetThymidine phosphorylase(Escherichia coli (strain SMS-3-5 / SECEC))
University of Karachi

LigandPNGBDBM50019242(CHEMBL3289117 | 2-(3',4'-Dihydroxyphenyl)q...)
Affinity DataIC50: 4.29E+4nMpH: 7.0Assay Description:TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 ยต...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019242(CHEMBL3289117 | 2-(3',4'-Dihydroxyphenyl)q...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetThymidine phosphorylase(Escherichia coli (strain K12))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50019242(CHEMBL3289117 | 2-(3',4'-Dihydroxyphenyl)q...)
Affinity DataIC50: 4.29E+4nMAssay Description:Inhibition of recombinant Escherichia coli thymidine phosphorylase using thymidine as substrate measured after 10 mins at 30 degC by spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019242(CHEMBL3289117 | 2-(3',4'-Dihydroxyphenyl)q...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed