BDBM50018671 CHEMBL3291019

SMILES Oc1ccc(CN(CC#C)C(CCC2CCN(Cc3ccccc3)CC2)C#N)c2cccnc12

InChI Key InChIKey=ATRSFRGWPPYVGZ-UHFFFAOYSA-N

Data  1 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50018671   

TargetAmine oxidase [flavin-containing] A(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of MAO-A in rat liver homogenate using [14C]-5HT as substrate preincubated for 30 mins followed by substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetCholinesterase(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant BuChE expressed in HEK293 cells using S-butyrylthiocholine iodide as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human recombinant MAOB using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant MAOA using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 6.17E+4nMAssay Description:Inhibition of MAO-B in rat liver homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of MAO-A in rat liver homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of MAO-B in rat liver homogenate using [14C]-phenylethylamine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 700nMAssay Description:Inhibition of MAO-A in rat liver homogenate preincubated for 240 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of MAO-A in rat liver homogenate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of MAO-A in rat liver homogenate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate preincubated for 240 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50018671(CHEMBL3291019)
Affinity DataKi:  1.21E+3nMAssay Description:Reversible inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed