BDBM50017876 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-ethyl-amino]-benzoylamino}-pentanedioic acid::CHEMBL22632

SMILES CCN(Cc1ccc2nc(N)[nH]c(=O)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key InChIKey=QJODZQWWCMYPFD-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50017876   

TargetThymidylate synthase(Lactobacillus casei)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50017876(CHEMBL22632 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-qui...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50017876(CHEMBL22632 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-qui...)
Affinity DataKi:  3.90nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017876(CHEMBL22632 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-qui...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of GAR transformylase isolated from the murine lymphoma cell line L5178YMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed