BDBM50017016 CHEMBL3287036

SMILES CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1

InChI Key InChIKey=MPZXLTZVPUSTFY-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50017016   

TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SphK1 using sphingosine as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human SphK2 using sphingosine as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of SphK2 (unknown origin) using sphingosine and [gamma-32P]ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of human recombinant SphK2 expressed in Sf9 cells assessed as radiolabeled products using 10 uM sphingosine and 10 uM gamma[32P]ATP by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of recombinant SK2 (unknown origin) using sphingosine as substrate and gamma[32P]ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of recombinant human SPHK2 at using sphingosine as substrate after 30 mins in presence of gamma-[32P]-ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of SK2 (unknown origin) expressed in cell lysates using Sph as substrate measured in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate assessed as inhibition constant by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed