BDBM50016986 7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-benzofuran-4-ol::CHEMBL17815

SMILES CCCc1cc(Cl)c2oc(Cc3ccc(OC)cc3)c(C)c2c1O

InChI Key InChIKey=PLRQEJPVGOQVSJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50016986   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-lipoxygenase reaction catalyzed by purified enzyme from porcine leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 36nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity towards soybean lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 11nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Pig)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity towards porcine 12-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of partially purified 15-lipoxygenase from human leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed