BDBM50015795 4-(4-Methyl-piperazin-1-yl)-[1,2,4]triazolo[4,3-a]quinoxaline::CHEMBL306316

SMILES CN1CCN(CC1)c1nc2ccccc2n2cnnc12

InChI Key InChIKey=UUBLPRADOSQTNR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50015795   

TargetAdenosine receptor A1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015795(CHEMBL306316 | 4-(4-Methyl-piperazin-1-yl)-[1,2,4]...)
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity towards the adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]CHA as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50015795(CHEMBL306316 | 4-(4-Methyl-piperazin-1-yl)-[1,2,4]...)
Affinity DataIC50: 2.30E+3nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50015795(CHEMBL306316 | 4-(4-Methyl-piperazin-1-yl)-[1,2,4]...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed