BDBM50015425 CHEMBL3265016

SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cc[nH]c3c2)cc1OC

InChI Key InChIKey=GTZLOTKHWGWBMF-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50015425   

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015425(CHEMBL3265016)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015425(CHEMBL3265016)
Affinity DataEC50:  94nMAssay Description:Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015425(CHEMBL3265016)
Affinity DataEC50:  2.79E+3nMAssay Description:Inhibition of Syk in goat antihuman IgE-induced CD63 expression in human whole blood by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed