BDBM50015405 CHEMBL3264637

SMILES Cc1ccc(cc1)-c1nn(cc1C(=O)Nc1ccc(C)c(c1)S(=O)(=O)N1CCOCC1)-c1ccc(Cl)cc1Cl

InChI Key InChIKey=WMANSNGQUXOIKU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50015405   

TargetBile acid receptor(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50015405(CHEMBL3264637)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human GST-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50015405(CHEMBL3264637)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of GW4064-induced transactivation of FXR (unknown origin) expressed in HEK293T cells after 16 hrs by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed