BDBM50015294 CHEMBL3263074::US9120798, 21

SMILES CC(C)(C)CN1CCC2(CN(c3c2c(Cl)ccc3O)c2ccccc2Nc2nnc(s2)-c2ccc(Cl)cc2)CC1

InChI Key InChIKey=NOPWGIRXRPXHPD-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50015294   

TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50015294(CHEMBL3263074 | US9120798, 21)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Yi receptors (The P2Yi receptor membranes were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
Go to US Patent

TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50015294(CHEMBL3263074 | US9120798, 21)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of P2Y1 receptor in human washed platelets assessed as decrease in 2-methylthio-ADP-induced calcium signal transduction pathway activation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50015294(CHEMBL3263074 | US9120798, 21)
Affinity DataKi:  13nMAssay Description:Displacement of [33P]2-MeS-ADP from human cloned P2Y1 receptor expressed in HEK293 cells by SPA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed