BDBM50015152 CHEMBL115468::N-hydroxy-1-naphthamide::Naphthalene-1-carboxylic acid hydroxyamide

SMILES c1ccc2c(c1)cccc2C(=O)NO

InChI Key InChIKey=JRZGPWOEHDOVMC-UHFFFAOYSA-N

Data  7 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50015152   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 4.30E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataKd:  5.00E+4nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Stromelysin (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Ithaca College

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human HDAC8 by [3H]acetyl histone peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Ithaca College

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human HDAC6 by [3H]acetyl histone peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ithaca College

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human HDAC1 by [3H]acetyl histone peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 4.30E+4nMAssay Description:Compound was tested for its in vitro inhibitory activity against RBL-1 5-LO (time dependent)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataKd:  5.00E+4nMAssay Description:Dissociation constant for Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataIC50: 4.27E+4nMAssay Description:Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed