BDBM50015005 CHEMBL3262093::US9259422, 13b, R = Ph-BU125::US9480684, 13b, R = Ph- BU125

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@]([H])([C@H](O)c4ccccc4)[C@]2(OC)C=C1)ccc3O

InChI Key

Data  9 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50015005   

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at human delta opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by beta-plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by beta-plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by beta-plate l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.21nM ΔG°:  -11.6kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.21nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-U69,593 from human kappa opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.84nM ΔG°:  -11.5kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.84nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  4.03nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  4.03nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent