BDBM50014983 1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-thione::CHEMBL278068

SMILES Fc1cc(F)cc(Cn2cc[nH]c2=S)c1

InChI Key InChIKey=WPMVQUHUCQAOBU-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50014983   

TargetDopamine beta-hydroxylase(Bovine)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against bovine adrenal dopamine beta-hydroxylase (DBH)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity was determined against bovine dopamine beta-hydroxylase (DBH)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 1.1-1.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.0-1.9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of dopamine beta hydroxylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014983(CHEMBL278068 | 1-(3,5-Difluoro-benzyl)-1,3-dihydro...)
Affinity DataKi:  41nMpH: 4.5Assay Description:Binding affinity towards Dopamine beta hydroxylase using tyramine substrate at pH 4.5 in the absence of fumarateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed