BDBM50014968 1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione::4-(2-Mercapto-imidazol-1-ylmethyl)-phenol::CHEMBL164747

SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1

InChI Key InChIKey=WVWZHFJGVDNBDA-UHFFFAOYSA-N

Data  3 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50014968   

TargetDopamine beta-hydroxylase(Bovine)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory activity was determined against bovine dopamine beta-hydroxylase (DBH)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Dopamine beta hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 0.4-1.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.3-4.6)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of dopamine beta hydroxylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataKi:  55nMpH: 4.5Assay Description:Binding affinity towards Dopamine beta hydroxylase using tyramine substrate at pH 4.5 in the absence of fumarateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataKi:  55nMpH: 4.5Assay Description:Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Bovine)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50014968(CHEMBL164747 | 4-(2-Mercapto-imidazol-1-ylmethyl)-...)
Affinity DataKi:  344nMpH: 6.6Assay Description:Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 6.6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed