BDBM50014707 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-propyl]-benzoylamino}-pentanedioic acid::CHEMBL431359

SMILES CC(Cc1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O)c1cnc2nc(N)nc(N)c2n1

InChI Key InChIKey=SEJWECNFKLVVFC-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50014707   

TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Concentration inhibiting GAR transformylase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Concentration inhibiting AICAR formyltransferase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration inhibiting thymidylate synthase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity towards dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataKi:  0.00520nMAssay Description:Concentration inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed