BDBM50013968 2-(2-Amino-4,5-dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide

SMILES CN(C1CCCC[C@@H]1N1CCCC1)C(=O)Cc1cc(Cl)c(Cl)cc1N

InChI Key InChIKey=WRHAGKLNUCUJGJ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50013968   

TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50013968(2-(2-Amino-4,5-dichloro-phenyl)-N-methyl-N-(2-pyrr...)
Affinity DataIC50: 12nMAssay Description:Binding affinity for sigma opioid receptor using [3H](+)-3-PPP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50013968(2-(2-Amino-4,5-dichloro-phenyl)-N-methyl-N-(2-pyrr...)
Affinity DataKi:  11nMAssay Description:Affinity of compound towards Sigma opioid receptor was determined in presence of [3H](+)-3-PPP radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50013968(2-(2-Amino-4,5-dichloro-phenyl)-N-methyl-N-(2-pyrr...)
Affinity DataKi:  523nMAssay Description:Affinity of compound towards Opioid receptor kappa 1 was determined in presence of [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50013968(2-(2-Amino-4,5-dichloro-phenyl)-N-methyl-N-(2-pyrr...)
Affinity DataKi:  1.54E+3nMAssay Description:Affinity of compound towards dopamine-D2 receptor was determined in presence of [3H](-)-sulpiride radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed