BDBM50013698 8-Phenyl-9H-purine-2,6-diamine::CHEMBL66077

SMILES Nc1nc(N)c2[nH]c(nc2n1)-c1ccccc1

InChI Key InChIKey=WGJICLLGFIVHNE-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50013698   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataIC50: 5.99E+4nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataIC50: 5.99E+4nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2019
Entry Details Article
PubMed
TargetVenus kinase receptor 2(Blood fluke)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataKd:  8.20E+4nMAssay Description:Binding affinity to Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013698(CHEMBL66077 | 8-Phenyl-9H-purine-2,6-diamine)
Affinity DataKi:  1.38E+5nMAssay Description:Binding affinity (Ki) against human phosphatidylinositol 4-kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2019
Entry Details Article
PubMed