BDBM50013169 CHEMBL3262620

SMILES Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCOC[C@@H]4N)cc4nc[nH]c(=O)c34)cccc12

InChI Key InChIKey=WCSCGZHKZNEMNJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50013169   

TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 37nMAssay Description:Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 299nMAssay Description:Inhibition of Syk in human whole blood assessed as inhibition of P-SLP76 in CD14+ monocytes by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 1nMAssay Description:Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product formation after 60 mins incubation by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 69nMAssay Description:Inhibition of Lyn (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 47nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 184nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50013169(CHEMBL3262620)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed