BDBM50013093 2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin-6-one::CHEMBL16026

SMILES CCc1cc(Nc2nc3nc[nH]c3c(=O)[nH]2)ccc1C

InChI Key InChIKey=JUIJZZPKQVQVDL-UHFFFAOYSA-N

Data  3 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50013093   

TargetThymidine kinase(HHV-2)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2019
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase (TK) assay for herpes simplex virus type 2 (HSV-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase (TK) assay for herpes simplex virus type 1 (HSV-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2019
Entry Details Article
PubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis (strain 168))
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibitory constant against DNA polymerases IIIC produced by Bacillus subtilis; (a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataKi:  1.76E+6nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase III subunit alpha(Bacillus subtilis (strain 168))
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50013093(CHEMBL16026 | 2-(3-Ethyl-4-methyl-phenylamino)-1,9...)
Affinity DataKi: >2.48E+5nMAssay Description:Inhibitory constant against DNA polymerases IIIE from Bacillus subtilis; (a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed