BDBM50012905 CHEMBL3261331::US20240059676, Compound MGL-3196::USRE46024, 8

SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O

InChI Key InChIKey=FDBYIYFVSAHJLY-UHFFFAOYSA-N

Data  4 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50012905   

TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  167nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  2.37E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetThyroid hormone receptor alpha(Human)
Aligos Belgium BV

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  5.93E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  73nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetThyroid hormone receptor alpha(Human)
Aligos Belgium BV

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  934nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  990nMAssay Description:Agonist activity at human THRbeta transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetThyroid hormone receptor alpha(Human)
Aligos Belgium BV

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  2.85E+3nMAssay Description:Agonist activity at human THRalpha transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  2.50E+3nMAssay Description:Huh7 cells were cultured in a DMEM medium supplemented with 10% FBS. The cells were inoculated into a 10 cm cell culture dish, proliferated to about ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetThyroid hormone receptor alpha(Human)
Aligos Belgium BV

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  7.90E+3nMAssay Description:Huh7 cells were cultured in a DMEM medium supplemented with 10% FBS. The cells were inoculated into a 10 cm cell culture dish, proliferated to about ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  192nMpH: 7.0Assay Description:Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetThyroid hormone receptor alpha(Human)
Aligos Belgium BV

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  2.74E+3nMAssay Description:Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivato...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  210nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Aligos Belgium BV

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  3.74E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed