BDBM50011995 (Hydroxy-naphthalen-2-yl-methyl)-phosphonic acid::CHEMBL26001::hydroxy(naphthalen-2-yl)methylphosphonic acid

SMILES OP(O)(O)C(=O)c1ccc2ccccc2c1

InChI Key InChIKey=UAGWYRYOBTXSBI-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50011995   

TargetInsulin receptor(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011995(CHEMBL26001 | hydroxy(naphthalen-2-yl)methylphosph...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of insulin receptor autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011995(CHEMBL26001 | hydroxy(naphthalen-2-yl)methylphosph...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50011995(CHEMBL26001 | hydroxy(naphthalen-2-yl)methylphosph...)
Affinity DataIC50: 4.40E+6nMAssay Description:The compound was evaluated for its binding affinity towards phosphotyrosine binding pocket of Src protein tyrosine kinase SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011995(CHEMBL26001 | hydroxy(naphthalen-2-yl)methylphosph...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011995(CHEMBL26001 | hydroxy(naphthalen-2-yl)methylphosph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human placental insulin receptor expressed in CHO cells assessed as decrease in insulin-stimulated [3H]-2-deoxyglucose uptake preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetInsulin receptor(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011995(CHEMBL26001 | hydroxy(naphthalen-2-yl)methylphosph...)
Affinity DataKi:  9.50E+4nMAssay Description:Non-competitive inhibition of human placental insulin receptor expressed in CHO cell membrane assessed as decrease in insulin-stimulated A2 phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed