BDBM50011760 1-(4-Amino-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione::CHEMBL287574::US10849982, Compd # 4

SMILES Nc1ccc(cc1)C12CC1C(=O)NC2=O

InChI Key InChIKey=SGGCPUGLXWOPAP-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50011760   

TargetAromatase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50011760(CHEMBL287574 | 1-(4-Amino-phenyl)-3-aza-bicyclo[3....)
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro inhibition of human placental Cytochrome P450 19A1 aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM50011760(CHEMBL287574 | 1-(4-Amino-phenyl)-3-aza-bicyclo[3....)
Affinity DataKd: >3.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetAromatase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50011760(CHEMBL287574 | 1-(4-Amino-phenyl)-3-aza-bicyclo[3....)
Affinity DataKi:  1.20E+3nMAssay Description:Apparent inhibition constant (Ki) for cytochrome P450 19A1 with androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed