BDBM50011696 CHEMBL170772::{1-[1-[1-Cyclohexylmethyl-2-(1-cyclohexyl-2-oxo-pyrrolidin-3-yl)-2-hydroxy-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H]1CCN(C2CCCCC2)C1=O

InChI Key InChIKey=PRTZELVVYWACOX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50011696   

TargetPepsin A(Pig)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011696(CHEMBL170772 | {1-[1-[1-Cyclohexylmethyl-2-(1-cycl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against PepsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011696(CHEMBL170772 | {1-[1-[1-Cyclohexylmethyl-2-(1-cycl...)
Affinity DataIC50: 500nMAssay Description:Inhibitory concentration against Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011696(CHEMBL170772 | {1-[1-[1-Cyclohexylmethyl-2-(1-cycl...)
Affinity DataIC50: 10nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetGastricsin(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011696(CHEMBL170772 | {1-[1-[1-Cyclohexylmethyl-2-(1-cycl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against GastricsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCathepsin E(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011696(CHEMBL170772 | {1-[1-[1-Cyclohexylmethyl-2-(1-cycl...)
Affinity DataIC50: 240nMAssay Description:Inhibitory concentration against cathepsin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed